Dupuytren’s Contracture in Alabama HFE Hemochromatosis Probands
نویسندگان
چکیده
BACKGROUND Dupuytren's contracture (DC) and HFE hemochromatosis occur in some of the same at-risk populations and present with similar comorbid conditions. METHODS We estimated DC prevalence in two cohorts of white Alabama hemochromatosis probands (294 C282Y homozygotes, 67 C282Y/H63D compound heterozygotes) in a retrospective study. We performed logistic regressions on DC using the following independent variables: age, body mass index, heavy ethanol consumption, serum ferritin, elevated serum AST/ALT, non-alcoholic fatty liver disease, viral hepatitis, cirrhosis, and diabetes. RESULTS One man and two women with C282Y homozygosity had DC (prevalence 1.02%; 95% CI 0.35%-2.96%). A man with C282Y/H63D had DC (prevalence 1.49%; 95% CI 0.26%-7.98%). DC occurred as an autosomal dominant trait in his kinship. In regression analyses, no single variable predicted DC. We observed no new DC cases after the diagnosis of hemochromatosis (mean follow-up 12.9 ± 7.5 years (1 SD), and 9.0 ± 5.1 years, respectively). CONCLUSIONS Our prevalence estimates of DC in white Alabama hemochromatosis probands are similar to those found in the white US population cohorts. DC risk was unrelated to the variables we studied.
منابع مشابه
Diabetes in first-degree family members: a predictor of type 2 diabetes in 159 non- screening Alabama hemochromatosis probands with HFE C282Y homozygosity Running head: Diabetes, family history, and hemochromatosis
Objective: We sought to identify predictors of diabetes diagnosed before hemochromatosis. Research Design and Methods: We studied these 16 variables in 159 non-screening hemochromatosis probands with HFE C282Y homozygosity: age; sex; body mass index (BMI); diabetes reports in first-degree family members (dichotomous); heavy ethanol consumption; cigarette smoking; elevated serum ALT/AST levels; ...
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OBJECTIVE We sought to identify predictors of diabetes diagnosed before hemochromatosis. RESEARCH DESIGN AND METHODS We studied these 16 variables in 159 nonscreening hemochromatosis probands with HFE C282Y homozygosity: age; sex; BMI; diabetes reports in first-degree family members (dichotomous); heavy ethanol consumption; cigarette smoking; elevated serum alanine aminotransferase/aspartate am...
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